Pre-clinical, investigational, and OTC compounds. Calibrated reads on what the data actually shows.
This category covers compounds that are either pre-clinical, FDA-approved for narrow indications and used off-label, or sold as supplements. Evidence quality ranges from robust (PT-141 for HSDD) to thin (Epitalon, NNMT inhibitors) to actively concerning (Melanotan II melanoma data).
We label every claim by confidence — well-established, emerging, community, or unknown. Read with the gradient in mind.
L-Carnitine L-tartrate · ALCAR · Acetyl-L-carnitine
Fatty-acid shuttle. Modest endurance and recovery benefits. Cognitive variant (ALCAR) for brain.
Bremelanotide · Vyleesi
Melanocortin receptor agonist. FDA-approved for HSDD. The non-vascular libido peptide.
5-Hydroxytryptophan
Direct serotonin precursor. Used for mood, sleep, and appetite. NEVER combine with SSRIs.
MT-II · MT2
α-MSH analogue. Tanning, libido, appetite suppression — and a significant melanoma risk profile.
Steroidal SARM
Steroidal SARM and myostatin modulator. Hepatotoxic — not a peptide; a synthetic steroid.
NNMT inhibitor · 5-amino-1-methylquinolinium
Small-molecule NNMT inhibitor. Strong preclinical metabolic data, no human trials.
NS2330
Triple monoamine reuptake inhibitor. ~10% weight loss in Phase II. Late-stage development.
Afamelanotide · Scenesse · MT-I
α-MSH analogue. EMA/FDA-approved (Scenesse) for erythropoietic protoporphyria.
(-)-Epicatechin · cocoa flavanol
Flavanol from cocoa. Modest myostatin inhibition. Best evidence: vascular function.
GH fragment (177-191)
GH fragment marketed for fat-loss. Mixed clinical data — most trials negative.
FST-344
Myostatin inhibitor. Powerful muscle-growth signal in animal models. Significant safety concerns.
Epithalon · AEDG
Tetrapeptide investigated for telomerase activation. Russian-language source base. Thin evidence.
KP-10 · Metastin (45-54)
Upstream HPG-axis trigger. Studied for hypothalamic infertility and as a GnRH alternative.
ActRIIB-Fc · Ramatercept
ActRIIB-Fc decoy receptor. Development discontinued due to side effects in trials.
Practically, it means the compound is sold without FDA approval for human use, often labeled "not for human consumption." Quality, dosing, and purity vary widely between suppliers, and third-party testing reveals frequent under-dosing and contamination.
PT-141 (bremelanotide) is FDA-approved for HSDD; Melanotan I (afamelanotide / Scenesse) is FDA-approved for EPP. Most others have only small pilot or animal data.
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